Lifetime History of Depression Linked with More Brain Plaques and Tangles, More Rapid Cognitive Decline in Alzheimer’s Disease
‘A lifetime history of depression is associated with increased plaques and tangles in the brains of those with Alzheimer’s disease and more rapid cognitive decline, according to a study in the February issue of Archives of General Psychiatry, one of the JAMA/Archives journals.
Previous studies have linked depression and Alzheimer’s disease, according to background information in the article. People with a lifetime history of major depressive disorder (MDD) may be more likely to be diagnosed with AD. In addition, both AD and MDD are likely to affect the brain’s memory-related temporal lobes.
MDD is likely to caused atrophy of the hippocampus, the area where the largest amounts of plaques and tangles form in patients with AD, the authors write.’
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