EMEA committee recommends antidepressant suicidality warnings

‘The EMEA has completed its review of two classes of antidepressants and concluded that they should not be used in children and adolescents except in their approved indications. An Agency committee has recommended that the drugs carry strong warnings about suicidality and hostility risks.

The review of serotonin-selective reuptake inhibitor (SSRI) and serotonin-norepinephrine reuptake inhibitor (SNRI) medicines looked at the potential risk of suicidal behavior in children and adolescents treated with these products.

The Agency’s scientific committee, the Committee for Medicinal Products for Human Use (CHMP), concluded at its 19-22 April 2005 meeting that suicide-related behavior (suicide attempt and suicidal thoughts), and hostility (predominantly aggression, oppositional behavior and anger) were more frequently observed in clinical trials among children and adolescents treated with these antidepressants compared to those treated with placebo.’

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